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Targeting tLNP

NeoVac uses proprietary and partnered lipids functionalized with ligands from small molecules to full antibodies to enable cell-specific targeting LNPs (tLNPs)

Internal synthesis of 

ligand-functionalized lipids

Different types of ligands that can be attached

Activated lipid scaffold

Ligand

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Small molecules

Carbohydrates

Glycomimetics

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Aptamers &

Oligonucleotides

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Amino Acids

& Peptides

Antibodies

Functionalized lipid

tLNP Manufacturing Technologies

NeoVac leverages proprietary technologies to enable seamless, accurate tLNP manufacturing process

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Manufacturing Complexity

3-step, complex manufacturing process

Microfluidic Synthesis

Chemical Conjugation

Chromatography

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Targeted IgGs

Unbound IgGs

Targeted IgGs

Nucleic acids

Lipid mix

Surface Chemistry

Uncontrollable surface chemistry required, leading to inefficient, inaccurate ligand binding

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Microfluidic Mixing

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1

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RNA in pH4.5 Buffer

Lipids in Ethanol

Target cells:

  • Antigen presenting cells

  • Blood cell (B-cells, T-Cells)

  • Inflammatory issue

  • Cancer cells

  • Endothelial cells

1-step, seamless manufacturing process

Ligands are already attached to lipids before LNP synthesis to ensure accurate ligand conjugation and avoid surface chemistry

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