Targeting tLNP
NeoVac uses proprietary and partnered lipids functionalized with ligands from small molecules to full antibodies to enable cell-specific targeting LNPs (tLNPs)
Internal synthesis of
ligand-functionalized lipids
Different types of ligands that can be attached
Activated lipid scaffold
Ligand
Small molecules
Carbohydrates
Glycomimetics
Aptamers &
Oligonucleotides
Amino Acids
& Peptides
Antibodies
Functionalized lipid
tLNP Manufacturing Technologies
NeoVac leverages proprietary technologies to enable seamless, accurate tLNP manufacturing process
Manufacturing Complexity
3-step, complex manufacturing process
Microfluidic Synthesis
Chemical Conjugation
Chromatography
Targeted IgGs
Unbound IgGs
Targeted IgGs
Nucleic acids
Lipid mix
Surface Chemistry
Uncontrollable surface chemistry required, leading to inefficient, inaccurate ligand binding
Microfluidic Mixing
1
RNA in pH4.5 Buffer
Lipids in Ethanol
Target cells:
-
Antigen presenting cells
-
Blood cell (B-cells, T-Cells)
-
Inflammatory issue
-
Cancer cells
-
Endothelial cells
1-step, seamless manufacturing process
Ligands are already attached to lipids before LNP synthesis to ensure accurate ligand conjugation and avoid surface chemistry