Malaria

Malaria remains a major global health threat, with the parasite having a complex life cycle

1. Malaria: Primarily caused by P. falciparum (most deadly) and P. vivax (relapsing infections), cycling through pre-erythrocytic, blood, and transmission stages

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2. Existing vaccines have limitations: Current vaccines (RTS,S & R21) only focus on the pre-erythrocytic stage, reducing infections but requiring multiple doses